Provider and pharmacist FAQ

RIGHTMED PHARMACOGENOMIC SOLUTION
What is the RightMed comprehensive test?

The RightMed comprehensive test is a provider-ordered pharmacogenomic test that covers hundreds of medications that treat a wide range of medical conditions, including psychiatric conditions, cancer, chronic pain, cardiovascular disease, and more. It analyzes a large set of genes that have been shown, based on OneOme’s rigorous research and standards for inclusion, to affect how a patient metabolizes many commonly prescribed medications.

Which medications are covered by the RightMed comprehensive test?

The test covers hundreds of medications. DOWNLOAD the full medication list.

Which genes are analyzed on the RightMed comprehensive test?

The list of genes on the OneOme RightMed pharmacogenomic test can be found HERE.

What is the RightMed Advisor?

The RightMed Advisor is an interactive tool that helps make pharmacogenomic test results actionable for providers. With the RightMed Advisor, providers can quickly and easily interpret test results, access OneOme’s expertly curated pharmacogenomic database, view pharmacogenomic clinical guidelines, evaluate drug-to-drug interactions, explore alternative medications, generate custom reports, and more.

ORDERING THE TEST
How is the RightMed comprehensive test ordered?

The RightMed test can be ordered several ways. Including by:

1) Filling out and returning a TEST REQUISITION FORM
2) Creating a PROVIDER PORTAL ACCOUNT and placing an order
3) Requesting a TEST KIT and returning the kit and test requisition form

For more information, please CONTACT US.

What is included with the RightMed comprehensive test?

OneOme offers an end-to-end solution that includes sample collection through either a buccal (cheek) swab kit that can be mailed to the patient's home or performed in the healthcare provider facility, or a blood sample. The test includes pharmacogenomic testing services, data analysis, clinical interpretation, the RightMed comprehensive test report, and several reporting options. In addition, OneOme has clinical pharmacists and client service representatives available to answer your questions.

Do I have to be an expert in genetics to order the RightMed comprehensive test?

No. In fact, we are committed to providing intuitive tools for providers to use to make pharmacogenomic test results actionable. We also have clinical pharmacists on staff that are available for consultations to review results and answer your questions.

Can pharmacists order the RightMed test?

In the United States, unless a pharmacist has a collaborative practice agreement in place, he or she cannot order the RightMed test. In certain countries (like Canada), pharmacists can order a RightMed test. Even though pharmacists usually cannot order the test, OneOme strongly believes that pharmacists play a critical role in pharmacogenomics. Visit ONEOME.COM/PHARMACIST to learn more.

Where is the RightMed test available?

OneOme offers its RightMed pharmacogenomic test in all U.S. states, except New York, and select international locations. In the near future OneOme plans to expand availability in New York, plus other international areas. Please CONTACT US for more information on availability within your area.

Does OneOme pay for shipping?

In most cases OneOme pays for both the shipping of the DNA test kit to the patient’s home and the return shipping to the OneOme laboratory.

Note: OneOme does not cover international return shipping.

Does your sample collection kit meet the packaging, shipping, and labeling guidelines for mailing biohazard (or biological) samples?

Our sample collection kit meets the FedEx packaging guidelines for clinical samples. This includes a watertight plastic tube for collection of the sample, which is placed in a watertight bio-specimen bag, which is then placed in a FedEx Clinical Pak for return shipment.

For additional details please visit ONEOME.COM/SAMPLE-REQUIREMENTS.

What is OneOme's sample retention policy?

OneOme retains DNA samples for up to 60 days from the date the report was released for purposes of quality assurance and/or to conduct follow up testing as requested by the provider.

RESULTS
How long does it take to receive the results?

OneOme’s turnaround time is, on average, four calendar days from receipt of sample.

What does the RightMed comprehensive test report look like?

View a sample RIGHTMED COMPREHENSIVE REPORT to see how test results are displayed. Additional sample reports are also available, including RIGHTMED ADVISOR CUSTOM REPORTS and the RIGHTMED PSYCHIATRY REPORT.

What is the RightMed psychiatry report?

The RightMed psychiatry report is an optional report that includes a subset of medications selected and classified by OneOme for use in the treatment of psychiatric conditions. Providers must order the RightMed comprehensive test, but can choose to receive this complimentary psychiatric-focused report in addition to the RightMed comprehensive test report. All medications featured on the psychiatry report are also on the comprehensive test report. The psychiatry report can be requested at the time of order or once the test results are available from the report center. Get a sample RIGHTMED PSYCHIATRY REPORT.

Can I create a report that focuses only on medications relevant to my patient?

Yes. By using the RightMed Advisor, you build custom reports that include only the medications that are relevant to you and your patient. These reports can be built either at the time of order or once the test results are available. View a sample RIGHTMED ADVISOR CUSTOM REPORT.

How do I use the CYP inhibitors and inducers table?

Understanding the major CYP(s) involved in a drug’s metabolism can aid the prescriber in limiting clinically relevant drug-to-drug interactions. OneOme prepared a LIST OF CYP INHIBITORS AND INDUCERS compiled from FDA labels and other professional references as a quick summary guide. Clinical information on specific drug-to-drug interactions is available through the RightMed Advisor.

BILLING
How much does the RightMed comprehensive test cost?

We offer a self-pay option for $249. Additionally, we offer insurance and institutional billing. When billing to insurance or an institution, the price may vary. Please visit ONEOME.COM/BILLING for more information on the cost of the RightMed test.

What are the billing options for the RightMed test?

At OneOme, our goal is to provide every patient with access to a RightMed test at the lowest price point available. That’s why we’ve created a billing process that supports multiple payment options including:

  • Patient self-pay
  • Institutional billing
  • Insurance billing

Visit ONEOME.COM/BILLING for more information.

What is your tax identification number?

OneOme’s Tax Identification Number is 46-4356584.

Where can I find a copy of your licenses and certifications?

OneOme’s licenses and certifications are available for reference and download at ONEOME.COM/LICENSING.

Does OneOme accept insurance?

Yes, you can choose to have OneOme bill your patient’s insurance (excluding Medicare and Medicaid) for the RightMed test at the time of the order. Learn more at ONEOME.COM/BILLING.

Which insurance companies are you contracted with?

OneOme’s goal is to gain in-network status with many private insurance companies. A list of insurance companies we are in-network with is available at ONEOME.COM/BILLING.

What is needed for OneOme to bill insurance?

The test requisition form (TRF) indicates the information needed for insurance billing. The billing section on the right-hand side of the page must be completed in its entirety before testing can begin. This includes additional information such as insurance information and reason(s) for testing. Payer-specific criteria are available at ONEOME.COM/BILLING.

Where is insurance billing available, and how do I proceed?

Insurance billing is available to all U.S. customers. Insurance billing can be selected as the billing option at the time of order on either our test requisition form or when ordering through OneOme’s provider portal.

If insurance has been verified and preauthorization obtained, why would a patient receive an invoice for charges (partial or total)?

Preauthorization does not guarantee payment. Insurance companies determine how much they will pay and what charges will be billed to the patient after a medical claim is filed. The patient is responsible for any portion of the test fee not covered by the insurance company for any reason including, but not limited to, copayments, co-insurance, unmet deductibles, or non-covered services.

Note: The patient is responsible for remitting any funds received directly from the insurance company to OneOme.

What are the specific CPT codes for the RightMed test?

It is the responsibility of the submitting party to determine the correct CPT codes to use when filing billing claims to third-party insurance.

Does OneOme participate in any Medicare or Medicaid plans?

At this time, OneOme does not currently bill Medicaid or Medicare plans. However, we offer a self-pay price of $249, plus interest free payment plans.

Does OneOme offer institutional billing?

Yes, OneOme provides the option to invoice the institution or provider directly. Visit ONEOME.COM/BILLING for more information.

Does OneOme offer patient self-pay?

Yes, we offer a patient self-pay price of $249. Payment can be made by credit card, health savings account (HSA), or Paypal. We also offer interest-free payment plans.

Does OneOme require pre-payment for patient self-pay testing?

Yes, we require payment before the test is processed in our lab.

What date of service does OneOme use?

The date of service (DOS) on the invoice is the date of sample collection. We won’t bill for services until the report has been sent to the ordering healthcare provider.

What are the payment terms for institutional billing?

Payment is due 30 days from the date of the invoice. Please CONTACT US to discuss payment plans, if necessary.

SCIENCE AND CLINICAL DEVELOPMENT
How does OneOme select which drugs to include on the RightMed test?

Drugs with professional guidelines from Clinical Pharmacogenetics Implementation Consortium (CPIC), Dutch Pharmacogenetics Working Group (DPWG), and the U.S. Food and Drug Administration (FDA) that are specific for a given drug-genotype or drug-phenotype relationship are assigned the highest priority for inclusion in the RightMed test. OneOme also curates and includes other medications for which metabolism has either been characterized with data on drug-to-drug interactions involving a gene, or the preponderance of scientific evidence demonstrates a clinical outcome associated with a genetic variant.

Is your technology based on cytochrome P450 (CYP450) genotyping?

Yes, the RightMed test includes several genes that are involved in the CYP450 pathway.

What type of methods does OneOme use for DNA analysis?

OneOme leverages PCR-based (polymerase chain reaction) methods for our genotyping and copy number variant analysis.

How is the OneOme database constructed?

The RightMed pharmacogenomic test, database, and reports were developed by utilizing complex multi-gene algorithms co-developed and exclusively licensed from leading pharmacogenomic experts at Mayo Clinic—Dr. John Black, Dr. Richard Weinshilboum, and Dr. Liewei Wang—on a rigorously tested genotyping technology platform.

We start by curating a list of drugs based on available clinical evidence from scientific literature and public and private databases (such as PharmGKB and Lexicomp). This information is summarized and reviewed by Mayo Clinic and our medical and scientific team of experts in pharmacology, bioinformatics, and genetics. Through this rigorous review, only drugs meeting an exacting level of evidence, as determined by the experts, are included in the database.

How does OneOme classify the level of evidence for each drug?

The “level of evidence” refers to the strength of scientific data supporting the association between a drug and a pharmacogene. OneOme’s classification scheme follows elements of the system developed by PHARMGKB, which classifies drugs on a scale of 1 to 4. Drugs with level 1 evidence have published practice guidelines for the use of genotyping and/or FDA package insert guidance for genotyping. These drugs have the most clinically actionable data and are noted on the report if applicable to the particular genotype or phenotype combination for that patient. Drugs with level 2 evidence have published clinical evidence of high quality that supports genotyping, but they do not have published specific practice guidelines. OneOme only includes drugs which fit within the definition of level 1 or level 2 as described above.

How are drugs classified on the OneOme report?

Based on the patient’s genotype and the algorithmic analysis, the final report shows a list of drugs classified by level of gene-drug interaction in a simple-to-use format: red (major gene-drug interaction), yellow (moderate gene-drug interaction), or green (minimal gene-drug interaction).

Technical support
What web browsers do you support for the OneOme portal?

OneOme’s online tools are best accessed using the most up to date web browser for your device with Chrome as the preferred browser for the optimal experience.

  • OneOme supports the following versions for each browser:
  • Chrome 50 or greater
  • Firefox 45 or greater
  • Safari 9.1 or greater
  • Edge 38 or greater
  • Internet Explorer 10 or 11
What web browsers do you support for the OneOme RightMed Advisor?

OneOme’s online tools are best accessed using the most up to date web browser for your device with Chrome as the preferred browser for the optimal experience.

  • OneOme supports the following versions for each browser:
  • Chrome 50 or greater
  • Firefox 45 or greater
  • Safari 9.1 or greater
  • Edge 38 or greater
  • Internet Explorer 10 or 11
COMPANY
What is OneOme’s relationship with Mayo Clinic?

The OneOme RightMed® comprehensive test was co-developed and exclusively licensed from Mayo Clinic.

Where is OneOme located?

OneOme is headquartered in Minneapolis, Minnesota.

How can I receive updates about OneOme?

SUBSCRIBE to receive email updates from OneOme, or follow us on LINKEDIN, TWITTER, or FACEBOOK.

What is OneOme’s privacy policy?

View OneOme’s PRIVACY POLICY. In general, except as described in our privacy policy, we do not disclose HIPAA-protected patient information to third parties without the patient’s consent.