Provider FAQ

What is OneOme’s relationship with Mayo Clinic?

The OneOme RightMed® pharmacogenomic test was co-developed and exclusively licensed from Mayo Clinic.

What does OneOme test for?

The OneOme RightMed pharmacogenomic test is a physician-ordered, comprehensive analysis that identifies how a patient may respond to certain medications. By analyzing 22 genes, the RightMed test provides prescription guidance for more than 340 common medications across multiple disease areas.

Is your technology based on cytochrome P450 (CYP450) genotyping?

Yes, the RightMed panel includes several genes that are involved in the CYP450 pathway.

What type of methods does OneOme use for DNA analysis?

OneOme leverages PCR-based (polymerase chain reaction) methods for our genotyping and copy number variant analysis.

Does OneOme pay for shipping?

Yes, in most cases, OneOme pays for shipping the DNA prescription test kit to the patient’s home and return shipping to the OneOme laboratory.

What medications are covered by the RightMed pharmacogenomic test?

The test covers more than 340 medications. Download the full list of medications.

What genes are analyzed on the RightMed pharmacogenomic test?

The list of genes on the OneOme RightMed pharmacogenomic test can be found here.

How long does it take to receive the results?

OneOme’s turnaround time is up to 7 - 10 calendar days from receipt of sample.

Does your sample collection kit meet the packaging, shipping, and labeling guidelines for mailing biohazard (or biological) samples?

Our sample collection kit meets the FedEx packaging guidelines for clinical samples. This includes a watertight plastic tube for collection of the sample, which is placed in a watertight bio-specimen bag, which is then placed in a FedEx Clinical Pak for return shipment.

For additional details please visit:

OneOme Process
How does OneOme select which drugs to include on the RightMed test? 

Drugs with professional guidelines from Clinical Pharmacogenetics Implementation Consortium (CPIC), Dutch Pharmacogenetics Working Group (DPWG), and the U.S. Food and Drug Administration (FDA) that are specific for a given drug-genotype or drug-phenotype relationship are assigned the highest priority for inclusion in the RightMed test. OneOme also curates and includes other medications for which metabolism has either been characterized with data on drug-drug interactions involving a gene, or the preponderance of scientific evidence demonstrates a clinical outcome associated with a genetic variant. 

How is the OneOme database constructed?

The RightMed pharmacogenomic test, database, and reports were developed by utilizing complex multi-gene algorithms co-developed and exclusively licensed from leading pharmacogenomic experts at Mayo Clinic—Dr. John Black, Dr. Richard Weinshilboum, and Dr. Liewei Wang—on a rigorously tested genotyping technology platform.

We start by curating a list of drugs based on available clinical evidence from scientific literature and public and private databases (such as PharmGKB and Lexicomp). This information is summarized and reviewed by Mayo Clinic and our medical and scientific team of experts in pharmacology, bioinformatics, and genetics. Through this rigorous review, only drugs meeting an exacting level of evidence, as determined by the experts, are included in the database.

How does OneOme classify the level of evidence for each drug?

The “level of evidence” refers to the strength of scientific data supporting the association between a drug and a pharmacogene. OneOme’s classification scheme follows elements of the system developed by PharmGKB, which classifies drugs on a scale of 1 to 4. Drugs with level 1 evidence have published practice guidelines for the use of genotyping and/or FDA package insert guidance for genotyping. These drugs have the most clinically actionable data and are noted on the report if applicable to the particular genotype or phenotype combination for that patient. Drugs with level 2 evidence have published clinical evidence of high quality that supports genotyping, but they do not have published specific practice guidelines. OneOme only includes drugs which fit within the definition of level 1 or level 2 as described above.

How are drugs classified on the OneOme report?

Based on the patient’s genotype and the algorithmic analysis, the final report shows a list of drugs classified by level of gene-drug interaction in a simple-to-use format: red (major gene-drug interaction), yellow (moderate gene-drug interaction), or green (minimal gene-drug interaction).

How is the RightMed pharmacogenomic test ordered?

Healthcare providers can create an account at or by clicking on the Log In button in the header of our website. Once the account has been set up, placing an order for a patient is a simple two-step process. For more information, please contact us.

Where is the RightMed pharmacogenomic test available?

OneOme offers its RightMed pharmacogenomic test in all U.S. states, except New York, and select international locations. In the near future OneOme plans to expand availability in New York and other international areas. Please CONTACT US for more information on availability within your area.

What is included in the cost of the RightMed pharmacogenomic test?

OneOme offers an end-to-end solution that includes sample collection—either a buccal (cheek) swab kit that can be mailed to the patient's home or performed in the healthcare provider facility, or a blood sample—pharmacogenomic testing services, data analysis, clinical interpretation, and an interactive report. In addition, OneOme has clinical specialists, pharmacists, and client service representatives available to answer your questions.

What web browsers do you support for the OneOme portal?

OneOme’s online tools are best accessed using the most up to date web browser for your device with Chrome as the preferred browser for the optimal experience.

OneOme supports the following versions for each browser:

  • Chrome 50 or greater
  • Firefox 45 or greater
  • Safari 9.1 or greater
  • Edge 38 or greater
  • Internet Explorer 10 or 11
What web browsers do you support for the OneOme RightMed Advisor?

OneOme’s online tools are best accessed using the most up to date web browser for your device with Chrome as the preferred browser for the optimal experience.

OneOme supports the following versions for each browser:

  • Chrome 50 or greater
  • Firefox 45 or greater
  • Safari 9.1 or greater
  • Edge 38 or greater
  • Internet Explorer 10 or 11
How do I use the CYP inhibitors and inducers table?

Understanding the major CYP(s) involved in a drug’s metabolism can aid the prescriber in limiting clinically relevant drug-to-drug interactions. OneOme prepared a LIST CYP INHIBITORS AND INDUCERS compiled from FDA labels and other professional references as a quick summary guide. Clinical information on specific drug-drug interactions is available through the RightMed Advisor.

What is OneOme's sample retention policy?

OneOme retains DNA samples for up to 60 days from the date the report was released for purposes of quality assurance and/or to conduct follow up testing as requested by the provider.

Security and Privacy
What is OneOme’s privacy policy?

View OneOme’s privacy policy. In general, except as described in our privacy policy, we do not disclose HIPAA-protected patient information to third parties without the patient’s consent.