Provider FAQ

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What is OneOme’s relationship with Mayo Clinic?

The OneOme RightMed® pharmacogenomic test was co-developed and exclusively licensed from Mayo Clinic.

THE ONEOME RIGHTMED PHARMACOGENOMIC TEST
What does OneOme test for?

OneOme is a physician-ordered, comprehensive, affordable, personalized analysis in pharmacogenomics. The RightMed pharmacogenomic test covers more than 340 prescription medications. The OneOme proprietary algorithms, and the platform for curating and interpreting data, was co-developed and exclusively licensed from Mayo Clinic’s 15+ years of experience in pharmacogenomic testing. Drug-to-drug interactions are also included in the report, providing physicians with actionable results.

Is your technology based on cytochrome P450 (CYP450) genotyping?

Yes, the RightMed panel includes several genes that are involved in the CYP450 pathway.

What type of methods does OneOme use for DNA analysis?

OneOme leverages PCR-based (polymerase chain reaction) methods for our genotyping and copy number variant analysis.

Does OneOme pay for shipping?

Yes, in most cases, OneOme pays for shipping the DNA prescription test kit to the patient’s home and return shipping to the OneOme laboratory.

What medications are covered by the RightMed pharmacogenomic test?

The test covers more than 340 medications. Download the full list of medications.

What genes are analyzed on the RightMed pharmacogenomic test?

The list of genes on the OneOme RightMed pharmacogenomic test can be found here.

How long does it take to receive the results?

OneOme’s turnaround time is 7 - 10 calendar days from receipt of sample.

Does your sample collection kit meet the packaging, shipping, and labeling guidelines for mailing biohazard (or biological) samples?

Our sample collection kit meets the FedEx packaging guidelines for clinical samples. This includes a watertight plastic tube for collection of the sample, which is placed in a watertight bio-specimen bag, which is then placed in a FedEx Clinical Pak for return shipment.

For additional details please visit: oneome.com/sample-requirements

OneOme Process
How does OneOme generate its drug list?

OneOme includes drugs with published practice guidelines for genotyping, those with FDA package insert guidance for genotyping, and drugs with published, high-quality clinical evidence that supports genotyping when using a specific drug.

How is the OneOme database constructed?

The RightMed pharmacogenomic test, database, and reports were developed by utilizing complex multi-gene algorithms co-developed and exclusively licensed from leading pharmacogenomic experts at Mayo Clinic—Dr. John Black, Dr. Richard Weinshilboum, and Dr. Liewei Wang—on a rigorously tested genotyping technology platform.

We start by curating a list of drugs based on available clinical evidence from scientific literature and public and private databases (such as PharmGKB and Lexicomp). This information is summarized and reviewed by Mayo Clinic and our medical and scientific team of experts in pharmacology, bioinformatics, and genetics. Through this rigorous review, only drugs meeting an exacting level of evidence, as determined by the experts, are included in the database.

How does OneOme determine the level of evidence for each drug?

The “level of evidence” refers to the strength of scientific data supporting the association between a drug and pharmacogenes. The classification system, developed by PharmGKB, classifies drugs on a scale of 1 to 4. Drugs with level 1 evidence have published practice guidelines for the use of genotyping or FDA package insert guidance for genotyping. These drugs have the most clinically actionable data and will be noted on the report using the “L1” icon. Drugs with level 2 evidence have published clinical evidence of high quality that supports genotyping, but specific practice guidelines have not been published. If a drug-gene relationship is only shown in a case report, it is a level 3 or 4 drug. OneOme only includes drugs from levels 1 and 2.

How are drugs classified on the OneOme report?

Based on the patient’s genotype and the algorithmic analysis, the final report shows a list of drugs classified in a simple-to-use format (red: use with great caution; yellow: use with caution; green: use as directed).

ORDERING THE ONEOME RIGHTMED PHARMACOGENOMIC TEST
How do I order the RightMed pharmacogenomic test for my patients?

Healthcare providers can create an account at https://portal.oneome.com or by clicking on the Log In button in the header of our website. Once the account has been set up, placing an order for a patient is a simple two-step process. For more information, please contact us.

Where is the RightMed pharmacogenomic test available?

OneOme offers its RightMed pharmacogenomic test in all U.S. states, except New York, and select international locations. In the near future OneOme plans to expand availability in New York and other international areas. Please CONTACT US for more information on availability within your area.

What is the price of the RightMed pharmacogenomic test?

OneOme offers an end-to-end solution that includes sample collection—either a buccal (cheek) swab kit that can be mailed to the patient's home or performed in the healthcare provider facility, or a blood sample—pharmacogenomic testing services, data analysis, clinical interpretation, and an interactive report. In addition, OneOme has clinical specialists, pharmacists, and client service representatives available to answer your questions.

What is included in the cost of the RightMed pharmacogenomic test?

OneOme offers an end-to-end solution that includes sample collection—either a buccal (cheek) swab kit that can be mailed to the patient's home or performed in the healthcare provider facility, or a blood sample—pharmacogenomic testing services, data analysis, clinical interpretation, and an interactive report. In addition, OneOme has clinical specialists, pharmacists, and client service representatives available to answer your questions.

What web browsers do you support for the OneOme portal?

OneOme’s online tools are best accessed using the most up to date web browser for your device with Chrome as the preferred browser for the optimal experience.

OneOme supports the following versions for each browser:

  • Chrome 50 or greater
  • Firefox 45 or greater
  • Safari 9.1 or greater
  • Edge 38 or greater
  • Internet Explorer 10 or 11
RESULTS
What web browsers do you support for the OneOme RightMed Advisor?

OneOme’s online tools are best accessed using the most up to date web browser for your device with Chrome as the preferred browser for the optimal experience.

OneOme supports the following versions for each browser:

  • Chrome 50 or greater
  • Firefox 45 or greater
  • Safari 9.1 or greater
  • Edge 38 or greater
  • Internet Explorer 10 or 11
What is the “normal” phenotype in the genotype results section?

Extensive metabolizers are considered the normal phenotype.

How do I use the CYP inhibitors and inducers table?

The CYP inhibitors and inducers table may be used as a guideline when prescribing drugs that may inhibit or induce a given CYP. Knowing the major CYP(s) involved in a drug’s metabolism can aid the prescriber in limiting clinically relevant drug-drug interactions. Find more information from the FDA here.

What is your sample retention policy?

OneOme retains any remaining sample that is not used during testing for 30 days and retains any unused extracted DNA for 60 days from the date the report was released.

Security and Privacy
What is OneOme’s privacy policy?

View OneOme’s privacy policy. In general, except as described in our privacy policy, we do not disclose HIPAA-protected patient information to third parties without the patient’s consent.